NSMB (Vol.21 (8), 2014)

This picture has been proposed to serve as a cover for Nature Structural and Molecular Biology journal (Vol. 21, issue 8, 2014) to illustrate the article from Fatma Guettou et al. : "Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2."1

In this article, structure of procaryotic integral membrane transporter PepTSo2 has been determined by X-ray crystallography in complex with three different peptides. Study of this protein is of high therapeutical importance due to its homology with human PepT1 and PepT2. By completing structural analysis with biophysical data, Fatma Guettou et al. identified three pockets in PepTSO2 binding-site which determine the selectivity of this protein towards specific amino acids.

A link to the full article can be found here.

The picture (which unfortunately hasn´t been selected to be the cover of this issue, we can not win every time) resumes the main findings of the article by presenting a toy box, the specificity pockets being depicted by amino acids-shaped holes on the sides of the box.

 

1.    Guettou F, Quistgaard EM, Raba M, Moberg P, Low C, Nordlund P. Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nature structural & molecular biology. 2014 Aug;21(8):728-31.